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Resets the Default Mode Network in the Brain
Psilocybin magic mushrooms have the ability to reset the typical control systems of cognition in the brain. Research shows that these compounds have an effect on the default mode network (DMN) in the brain, which is a large-scale brain network of interacting brain regions. The DMN is known to be overactive in people with depression. Microdosing can reset this system and help regulate it in a positive way, which allows for a clearer thought process and better creativity and mood.
The Difference between Microdosing Mushrooms and Prescription Antidepressants
Researchers believe that psilocybin magic mushrooms help to revive emotional responsiveness in the brain. This mechanism is the opposite effect of antidepressant drugs called selective serotonin reuptake inhibitors (SSRIs). Psilocybin mushroom assisted therapy can mitigate depression by increasing emotional connection. New research published in the journal Neuropharmacology examined patients diagnosed with moderate-to-severe treatment-resistant depression to investigate what kinds of effects psilocybin would have on their brain activity and depressive symptoms. Previous research shows that psilocybin mushrooms can reset brain circuits in depressed people, with benefits lasting up to five weeks after treatment. This new research shows that psilocybin heightens the activity in the right amygdala.
Some people under specific circumstances shouldn’t ingest a psychedelic substance without consulting a qualified health-care practitioner beforehand. You should buy shrooms from a reliable online dispensary in Canada like Weedsmart to avoid adverse effects.
- Women who are pregnant or breastfeeding
- People who are using lithium
- People who are using tramadol
- People who are taking antidepressants have special considerations to be aware of. Please read the information below.
Here is some more information about precautions and potential side effects that you should be aware of.
Benefits of Micro dosing magic mushrooms:
Searching for a natural alternative of prescribed medicines, Psilocybin mushrooms are making a name for themselves. Every person is trying to make his or her life better by gaining the extra edge provided by the mushroom. No matter if you are an artist, athlete, or a 9 to 5 employee you want to clear your creative blocks or increase the stamina to perform better in the field or absorb all the office tension without disturbing your health, the magic mushroom is there to help you out. Psilocybin or magic mushrooms are naturally occurring mushrooms with psychoactive properties. According to the current laws, as psilocybin mushrooms contain psychoactive molecules, they are illegal and considered as a drug. The case of the magic mushroom is similar to marijuana.
Benefits of magic mushrooms:
Not knowing what magic mushrooms are and you search them on the internet, you will notice that psilocybin mushrooms are classified as Schedule I drug which means that it is illegal to buy or use magic mushrooms. In the headlines, no one is claiming that magic rooms have too many health benefits. Patients were showing severe symptoms of anxiety, depression, loss of appetite, and losing the will to live. They were treated with microdosing Get Kush magic mushrooms and the remarkable results were shown by all the patients. Doctors witnessed that patients were showing fewer signs of anxiety, depression, and relief from chronic pain. The research opened new doors for researchers to invest more time and effort in magic mushrooms and explore more therapeutic properties that include growth and repair of brain cells to overcome fearful stimuli. Depression is one of the major issues that our society faces these days and psilocybin mushroom can elevate the depression.
What Are the Benefits of Microdosing?
Microdosing mescaline offers similar benefits to LSD and magic mushrooms. People most commonly microdose for the following reasons:
- Boost creativity
- Facilitate productive flow states
- Improve mood
- Bolster empathy and connection with others
- Achieve deeper states of meditation and self-awareness
- Establish new habits and cognitive patterns
However, is the practice effective? There’s no science to back it up yet, but plenty of anecdotal evidence suggests it is.
A recent study in the Harm Reduction Journal sought to figure out why people took microdoses of psychedelics like mescaline.
In this study, 278 respondents taking a variety of psychedelics responded to a survey with their personal testimony. These questions regarded the topic of what microdosing helps them with — in their opinion.
The following list is the response of these participants. It’s important to keep in mind that this is not a scientific evaluation but, rather, a self-reported benefit of the microdose experience.
While readers should not consider this proof of effectiveness per se, these are the perceived benefits that proponents of microdosing claim to experience [4]:
- Improved Mood — 26%
- Better Focus — 14.8%
- Higher Levels of Creativity — 12.9%
- Improvements in “Self-Efficacy” — 11.3% (note: this refers to things like improving your motivation and ambition as well as how productive or “effective” your actions are.)
- Increased Energy — 10.5%
- Better Sociability — 7.6%
- Higher Cognitive Ability — 5.8%
- Reduction in Anxiety — 4.2%
- Visual / Physiological Enhancement — 3%
- Other Benefits — 2.2%
- Reduction of Other Symptoms — 1.1%
Some seek out microdosing as a possible treatment for their attention, depression, and anxiety disorders. While there have been some anecdotal reports of success with this, it’s vital to never attempt this on your own.
Never give up or change your medication without the express permission of your physician or therapist.
Frequency: How Often Should You Microdose Mescaline?
There are three different schools of thought when it comes to how frequently you microdose. Ultimately, it’s up to each individual to feel out the right schedule for themselves.
As far as the most common options go, these include:
- Dose, break, break (AKA the “Dr. Fadiman Standard”)
- A week on, a week off
- Work days only (5 on, 2 off)
The main thing to keep in mind is that it’s important to take breaks. Most psychedelics build tolerance quickly, so it’s important to give enough time for the drug to leave your system fully, or you’ll miss out on its benefit.
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Dosage: How Much Mescaline to Take For a Microdose
There are several different forms of mescaline — each one requires some changes in dosing. Since it naturally occurs in many kinds of cacti, it can be as easy as eating a little bit of a cactus every day — though, be warned, the taste is not something you’ll grow to love.
Below is a breakdown of some of the different types of mescaline out there and what it means to use them for a microdose.
Mescaline Dosage Chart: Microdosing
Source | Microdose |
Peyote | 1 gram |
San Pedro (Huachuma) | 1-2 grams |
Peruvian Torch | 5–10 grams |
Pure Mescaline | 10–40 milligrams |
Microdosing Mescaline Isolate
Microdose levels: 10–40 milligrams
Mescaline isolate is one of the easiest ways to consume your mescaline microdose. This consists of small amounts of powder that you can easily put into a shot glass and shoot back with water or juice.
Some also like the isolate because they can add it to their morning cup of coffee or smoothie.
You can also make mescaline microdose capsules using raw isolate powder.
If you’re using this form of mescaline, test a sample of the powder with a test kit to ensure it’s safe and pure.
Microdosing San Pedro Cactus (Echinopsis pachanoi)
Microdose Levels (dried): 1–2 grams
San Pedro grows very fast, but its mescaline content is much more comparable to peyote than Peruvian Torch. San Pedro is legal to buy, own, and grow, though it’s still technically illegal to consume — these facts make it a popular option.
The mescaline content is lower than peyote — you’ll need to take about twice as much to get the same effects. In the case of microdoses, this isn’t much of a problem.
You can take san pedro cactus powder by filling it into capsules (you’ll need about 2 or 3 standard 00 capsules for a single 1–2 gram dose) or mixing the bitter powder with some water or juice.
Microdosing Peyote (Lophophora williamsii)
Microdose Levels (dried): 1 gram
Peyote is by far the most popular mescaline-containing cacti. While concentrations vary from cactus to cactus, peyote is much stronger than the other options by volume.
That popularity is a double-edged sword, however. As more people find interest in mescaline and turn to peyote, it is at risk of endangerment. For this reason — and because it’s illegal to buy or own — we recommend either the isolate or san pedro cactus as your source of mescaline instead.
You can take peyote by eating small chunks of the dried buttons or mixing the powder into water or juice.
Be warned: none of these cacti taste very good; you’ll want to chase the taste back with something.
Microdosing Peruvian Torch Cactus (Echinopsis peruviana)
Microdose Levels (dried): 5–15 grams
Many love this cactus for its ability to grow fast, but it also contains the least amount of mescaline compared to the other options, so you’ll have to consume more.
That said, this is a legal cactus to own and grow, but it’s still illegal to consume or extract it. Regardless, this cactus is easy to get your hands on in most parts of the world.
You may even find this cactus at a local Home Depot or garden shop!
Frequency: How Often Should You Microdose Mescaline?
There are three different schools of thought when it comes to how frequently you microdose. Ultimately, it’s up to each individual to feel out the right schedule for themselves.
As far as the most common options go, these include:
- Dose, break, break (AKA the “Dr. Fadiman Standard”)
- A week on, a week off
- Work days only (5 on, 2 off)
The main thing to keep in mind is that it’s important to take breaks. Most psychedelics build tolerance quickly, so it’s important to give enough time for the drug to leave your system fully, or you’ll miss out on its benefits.
Safety: Microdosing Mescaline
There’s no reason to expect mescaline to be dangerous at any level of regular use. Scientific reporting suggests a similar safety profile to other psychedelics — noting a particularly low potential for overdose and abuse [2].
The LD50 of mescaline — or the amount you would have to consume for half of the people doing so to die — would be “incredibly difficult for anyone to be able to consume” [3]. No exact LD50 has been identified with mescaline, but studies in humans involving doses as high as 800 mg were well-tolerated.
To put this into perspective, the standard psychedelic dose of mescaline is just 200 mg, and a microdose is closer to 20 mg.
While it’s unlikely for someone to overdose on mescaline, that doesn’t mean it’s perfectly safe.
All psychedelics carry some potential side effects. Most of these are cognitive (anxiety, paranoia), but some are physical (vasoconstriction and increased heart rate).
Typically, the physical impact of mescaline is no more serious than exercise (increased heart rate and elevated blood pressure).
However, in those with a weak heart or who are taking drugs that alter heart rate and blood pressure, mescaline could increase the risk of adverse side effects.
The other risk when it comes to psychedelics concerns mental health. Research is still unclear on the impacts, but mescaline could worsen symptoms of schizophrenia, bipolar disorder, or other pre-existing mental health disorders.
In very rare cases, it’s led to a condition called hallucinogen-persisting perception disorder (HPPD) — which involves hallucinations lasting weeks, months, or even years after the experience.
These are very unlikely when used in microdoses — but the risks are still
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